Sports betting is illegal in Missouri but fantasy sports betting is not. 

With the busiest fantasy sports betting season around the corner, Cameron Conner had a chance to chat with Missouri Gaming Commission Chairman Mike Leara to discuss the difference between the legality of betting on fantasy sports and general sports. (LISTEN 13:03)

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https://www.missourinet.com/2022/08/24/missouri-gaming-commission-explains-its-role-in-fantasy-sports-betting-listen/